Snail1-expressing fibroblasts as a source of paracrine signals in colon cancer tumors
نویسندگان
چکیده
The transcription factor Snail1 is involved in the acquisition of invasive properties during the epithelial-mesenchymal transition. Snail1 expression in tumor stroma is associated with lower specific survival in colon cancer patients. Nevertheless, the role of Snail1 expression in stroma has not been determined. Using human primary normal and cancer associated fibroblasts (CAFs), fibroblastic cell lines and xenografted models of colon cancer, we show that Snail1 expression in fibroblasts and CAFs enhances the tumorigenic capacity of colon cancer cells by altering the secretion of cytokines.
منابع مشابه
Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells.
Snail1 is a transcriptional factor that plays an important role in epithelial-mesenchymal transition and in the acquisition of invasive properties by epithelial cells. In colon tumors, Snail1 expression in the stroma correlates with lower specific survival of cancer patients. However, the role(s) of Snail1 expression in stroma and its association with patients' survival have not been determined...
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تاریخ انتشار 2015